Eighteen arrests were made during the month-long operation codenamed Operation Machinize.
Throughout October, Sussex Police worked alongside Trading Standards and the Home Office's Immigration Enforcement, targeting 76 addresses across the county.
More than £30,000 in cash was seized, as well as tens of thousands of cigarettes and multiple kilos of tobacco
Premises targeted in the operation, coordinated by the National Crime Agency, included car washes, barbers shops, nail bars and convenience stores.
Test purchases were also made to check for sales of age-restricted goods, such as cigarettes and tobacco.
Sussex Police A close up of an officer's hands wearing blue latex gloves counting paper cash.Sussex Police .Police seized more than £30,000 in cash during the raids
Det Ch Insp Anthony Leadbeatter said: "Sussex Police proactively tackles money laundering and works to keep vulnerable people in our communities safe from exploitation every day.
"Operations such as Machinize, however, are opportunities to intensify our focus on these areas, cracking down on criminality and building our intelligence to support future work."